Ananya Aesthetics
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Platelet Rich Fibrin

What is Platelet Rich Fibrin (PRF)?

PRF, or platelet-rich fibrin, is the next generation treatment of platelet concentrate. PRF is a fibrin matrix comprised of platelet cytokines, growth factors and cells used to help promote skin rejuvenation, hair growth and wound healing.
How is PRF obtained?

  1. First, we do a simple blood draw into tubes.
  2. The tubes are then centrifuged for 5 minutes.
  3. The tubes are taken out of the centrifuge and the top portions of the centrifuged tubes are drawn up to obtain the PRF for clinical treatment.

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More Cells=More Growth Factors
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FIBRIN SCAFFOLD = LONGER RELEASE OF GROWTH FACTORS
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The blood that is collected for PRF is spun in a special low-speed centrifuge – the EZMINISPIN – to isolate the platelets and white blood cells from the red blood cells. In order to obtain PRP, on the other hand, it is necessary to spin the tubes at up to 6x the G-Force of the EZPRF process. The reason the centrifuge is spun at much higher rate to obtain the PRP is to eliminate all Red Blood Cells (RBC) by pushing them down with gravitational force. This is a good idea; however, by spinning the tube too fast for too long will also eliminate the good cells that we DO want.

The tubes are 100% Natural and devoid of any anticoagulant or additives. As a result, fibrinogen molecules can be converted to thrombin into fibrin during the blood clot formation.

Because there is no anticoagulant in the tube that the blood is collected, the plasma actually forms a platelet and white blood cell-rich fibrin scaffold once injected into the treatment area. The fibrin clot allows for a much slower and longer release of the growth factors and cytokines (up to 1 week versus few hours with PRP), again resulting in more clinical results.

Because the blood is spinning at very low g-force to obtain the PRF, the platelet recovery is close to 100% with the PRF.  We are also using only 1/10th of the volume collected. Hence, PRF contain more platelets per mcL than PRP. Additionally, PRF also has leukocytes (WBC) & mesenchymal stem cells, unlike PRP, resulting in more potential clinical results.
How Does PRF Work?Fibrin is a biological scaffold that forms in response to an injury anywhere in the body. Platelets circulating in the blood will bind to a scaffold of fibrin. When platelets bind to the fibrin scaffold, they become activated and release growth factors, which start the wound healing process by creating new skin cells, collagen and blood vessels. By injecting PRF into an area on the face or scalp, a controlled inflammatory response is created, which kick starts new cell growth and collagen production.

How Is PRF Used?PRF is used to address many of the same issues as PRP, but PRF releases growth factors for much longer, up to one week, versus PRP which releases growth factors for few hours. This means that PRF could have better longer-term benefits. The growth factors are what stimulate the stem cells to improve collagen and elastin in the skin. The platelets in PRF are thought to be more robust than those in PRP, and to therefore promote faster healing.

The prepared PRF is immediately ready for injection into the face to fill facial folds and wrinkles, to plump the hollows under the eyes and dark circles, and to improve skin tone and texture. The PRF can also be injected into the scalp to aid with hair restoration and growth.  
How Does PRF Treat The Undereye Loose Skin And Dark Circles?The skin under the eyes is one of the thinnest skin on our body. It can be one of the first areas that show signs of aging.  PRF is one of the ideal treatments that improves this area and can be a better option than heat-based skin tightening devices.
​

PRF can also enhance the results of fillers under the eyes. Injecting fillers under the eyes, like Vollure, can instantly improve the hollowness under the eyes and is a fabulous treatment to instantly rejuvenate this area. However, too much fillers under the eyes can make the eyes look puffy or cause a bluish tinge if injected too superficially. Also, it can be very difficult to treat the dark circles only with fillers. Injecting PRF in additional to the fillers can significantly enhance the results of the fillers by tightening the loose skin under the eyes and improving the dark circles.
Ananya Aesthetics LLC, DBA Ananya Aesthetics is the MSO for ZKN Medical Corporation.  Medical director Luani Lee, M.D. 

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What Our Clients Are Saying

I love this med spa. The service is very personalized and they are following your results as much as you are. I got Botox here and was pleasantly surprised that they started it with a facial that was so relaxing. I'm thrilled with my results and couldn't recommend them enough!."
-Amy W.

"I followed Dr. Sam to her own practice because she is simply the best person for lip injections in LA if you're looking for a natural look. I've had people tell me I have the best looking lips they've ever seen-- most of them didn't even know they were from injections. Dr. Sam works around what you're looking for and gives you the perfect shape. Loyal customer for life!"  -Charlotte C. 

Contact Us

Serving the cosmetic needs of Pasadena and North East Los Angeles areas such as Glendale, Burbank, Arcadia, Altadena, San Marino, and Sierra Madre.  Our experienced staff specializes in customized treatment plans to meet your individual needs.  These treatment plans may include Botox, Dermal Filler, Platelet Rich Fibrin (PRF), Microneedling, Laser Hair Removal, The Confidence Laser, Anteage MD microneedling, Exosomes, Hair Restoration, Acne, Spider Veins, Melasma, Rosacea, Skin Tightening, Skin Rejuvenation Escarglo-needling, Kybella, IV Therapy, Vitamin Shots.
Copyright 2022, Ananya Aesthetics
766 E. Colorado Blvd., Ste 107
​Pasadena, CA 91101
  • Home
  • Self Care Membership
  • Skin Concerns/Treatments
    • Treatments by Skin Concern >
      • Acne
      • Hyperpigmentation
      • Acne Scarring/Uneven Texture
      • Redness/Rosacea
      • Spider Veins/Telangiectasia/Leg Veins
      • Skin Laxity/Volume Loss/Loose Skin
      • Wrinkles/Crepe Skin
      • Unwanted Hair
      • Pseudofolliculitis Barbae/Ingrown Hairs
      • Dark Undereyes/Dark Circles
      • Tired Looking Eyes
      • Psoriasis
      • Cherry Angiomas
      • Skin Tags/Moles
      • Nail Fungus
      • Bruising
      • Excessive Sweating / Hyperhydrosis
    • Service Treatments >
      • The Consultation: It's All About You
      • Neurotoxin: Botox/Dysport/Xeomin/Daxxify/Jeuveau
      • Botox for Excessive Sweating
      • Dermal Fillers
      • Filler Dissolving: Hyaluronidase
      • Sculptra Aesthetics >
        • Sculptra Butt Lift
      • Microneedling
      • Escarglo-needling
      • Platelet Rich Fibrin (PRF)
      • Laser Treatments >
        • The Confidence Laser Treatment >
          • The Confidence Laser Treatment with Neo Skin
          • The Confidence Laser Treatment with Neo Clear Acne Treatment
      • Microinfusion
      • The Unicorn Facial: WIQO PRX-T33 Bio Revitalization
      • TCA Cross
      • Kybella
      • Skin tag/mole/sun spot removal
      • Acne/Ingrown Extractions
      • Cortisone Injections
      • Cosmelan MD
      • Wellness/IV Therapy
      • Vitamin Shots
  • Shop
    • Gift Cards
    • Lifestyle >
      • Candles >
        • Sofia Candle 7.5 oz.
        • Sofia Candle 14 oz.
        • Sofia Candle 24 oz.
        • Rose Marie Candle
    • Skincare >
      • Shop By Concern >
        • Antiaging
        • Acne
        • Dry Skin
        • Sensitive Skin / Rosacea
        • Dark Spots/Hyperpigmentation
        • Tone and Texture
        • Keratosis Pilaris
      • Shop All
      • Skin Integrity Skincare
      • Defenage >
        • Defenage Clinical Trio
        • Defenage 3D Eye Cream
      • AnteAGE MD
      • Cyspera >
        • Cyspera Intensive Single (Not the Kit)
        • Cyspera Intensive System
    • CO 2 Lift Carboxy Therapy Mask
    • Upneeq >
      • Upneeq Box of 45
      • Upneeq 5 Pack
    • Latisse
    • Accessories >
      • Silicone Facial Mask Brush Set
      • Silk Headband
  • About Us
    • Policies
    • Terms of Use
    • Privacy Policy
  • Gallery
    • Botox/Dysport/Jeuveau Before and After
    • Dermal Filler Before and After
    • Sculptra Before and After
    • Microneedling Before and After
    • Qwo Before and After
    • Kybella Before and After
    • Cortisone Injections Before and After
  • MEDIA
    • CBS
    • Blog >
      • 4 Skincare Serums You Need to Know About
      • What the Kardashians Have Done for the World of Minimally Invasive Aesthetic Medicine
      • Prevention Vs. Maintenance Vs. Correction
      • 5 Types of Wrinkles and How to Treat Them
      • The BIG Event Guideline
      • Everything Sunscreen
      • Benefits of Carbon Dioxide
      • When to Schedule
  • REVIEWS
  • Promotions
  • Contact Us
  • FREQUENTLY ASKED QUESTIONS
    • What is the difference between microneedling devices?
    • RETIN-A AND HYDROQUINONE INSTRUCTIONS
  • Price List
  • COVID-19 Updates
  • Xeomin offer video